dna ubiquitination proteins online manufacturer Manufacturer

Met1-Diubiquitin,Catalog Number: U2101,Lyophilized,Purity95% Met1-Diubiquitin chains are manufactured using recombinant methods. Met1-linked ubiquitin chains are key regulators of inflammation and immunity to pathogens. Met1-linked ubiquitin chains are assembled by LUBAC and are disassembled by the deubiquitinases OTULIN and CYLD. Met1-linked ubiquitin chains function as kinase scaffolds to control signalling outcomes by pattern recognition receptors and cytokine receptors.

K6-Diubiquitin,Catalog Number: U2201,Lyophilized,Purity95% This K6 linked di-ubiquitin was obtained by chemical synthesis. K6 linked ubiquitin linkages are found at increased levels in response to UV radiation, indirectly associated with DNA repair, and have been identified on mitochondrial outer membrane (MOM) proteins. Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australia,Asia,Middle East,Africa

K63-Diubiquitin,Catalog Number: U2801,Lyophilized,Purity95% This K63 linked di-ubiquitin was obtained by chemical synthesis. K63-linked polyubiquitin chains exert nonproteolytic functions in vivo, such as protein trafficking, kinase/phosphatase activation, and DNA damage control, all of which might be important in regulation of cancer survival and development. The array of cellular processes initiated and regulated by ubiquitin has been partially explained by the structural

Types of histone modification Chromatin architecture, nucleosomal positioning, and ultimately access to DNA for gene transcription, is largely controlled by histone proteins. Each nucleosome is made of two identical subunits, each of which contains four histones: H2A, H2B, H3, and H4. Meanwhile, the H1 protein acts as the linker histone to stabilize internucleosomal DNA and does not form part of the nucleosome itself. Histone proteins undergo post-translational modification

H2A-K13Ub Catalog Number H1401 Store at -20C or -80C This product is chemically synthesized histone H2A protein (1-129, human) with mono-ubiquitination at K13. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. RNF168-mediated ubiquitination of histone H2A Lys13,15 (H2AK13,15ub) at DNA double-strand breaks (DSBs) is crucial for preventing aberrant DNA repair and maintaining

H2A-K15Ub Catalog Number H1402 Store at -20C or -80C Chemically synthesized histone H2A protein (1-129,human) with mono-ubiquitination at K15. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. RNF168-mediated ubiquitination of histone H2A Lys13,15 (H2AK13,15ub) at DNA double-strand breaks (DSBs) is crucial for preventing aberrant DNA repair and maintaining genome stability.

H2A.ZK121Ub Catalog Number H1404 Store at -20C or -80C Chemically synthesized histone H2A.Z protein corresponding to residues with monoubiquitination K121 modification. The histone variant H2A.Z has been implicated in nucleosome exchange, transcriptional activation and Polycomb repression. H2A.Z has been shown to be subject to C-terminal ubiquitination by the PRC1 component Ring1B. Histone H2AZ is a variant of histone H2A, and is used to mediate the thermosensory response,