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K63-Diubiquitin,Catalog Number: U2801,Lyophilized,Purity≥95%
This K63 linked di-ubiquitin was obtained by chemical synthesis.
K63-linked polyubiquitin chains exert nonproteolytic functions in vivo, such as protein trafficking, kinase/phosphatase activation, and DNA damage control, all of which might be important in regulation of cancer survival and development.
The array of cellular processes initiated and regulated by ubiquitin has been partially explained by the structural diversity of differently linked ubiquitin chains. In a ubiquitin chain, ubiquitin moieties can be conjugated through one of their lysine residues (K6, K11, K27, K29, K33, K48 and K63) or the N-terminal methionine residue (M1), offering countless possibilities to assemble a specific polymer. Ubiquitin molecules can also be modified by other post-translational modifications, including acetylation and phosphorylation, adding another layer of ubiquitin signal regulation and diversification. This K63 linked di-ubiquitin was recombinantly expressed in E. coli, enzymatically conjugated, and purified via liquid chromatography.
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australia,Asia,Middle East,Africa
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K63-Diubiquitin,Catalog Number: U2801,Lyophilized,Purity≥95%
This K63 linked di-ubiquitin was obtained by chemical synthesis.
K63-linked polyubiquitin chains exert nonproteolytic functions in vivo, such as protein trafficking, kinase/phosphatase activation, and DNA damage control, all of which might be important in regulation of cancer survival and development.
The array of cellular processes initiated and regulated by ubiquitin has been partially explained by the structural diversity of differently linked ubiquitin chains. In a ubiquitin chain, ubiquitin moieties can be conjugated through one of their lysine residues (K6, K11, K27, K29, K33, K48 and K63) or the N-terminal methionine residue (M1), offering countless possibilities to assemble a specific polymer. Ubiquitin molecules can also be modified by other post-translational modifications, including acetylation and phosphorylation, adding another layer of ubiquitin signal regulation and diversification. This K63 linked di-ubiquitin was recombinantly expressed in E. coli, enzymatically conjugated, and purified via liquid chromatography.
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australia,Asia,Middle East,Africa