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Met1-Diubiquitin,Catalog Number: U2101,Lyophilized,Purity≥95%
Met1-Diubiquitin chains are manufactured using recombinant methods.
Met1-linked ubiquitin chains are key regulators of inflammation and immunity to pathogens. Met1-linked ubiquitin chains are assembled by LUBAC and are disassembled by the deubiquitinases OTULIN and CYLD. Met1-linked ubiquitin chains function as kinase scaffolds to control signalling outcomes by pattern recognition receptors and cytokine receptors. Intracellular bacteria are decorated with Met1-linked ubiquitin chains for activation of xenophagy. Pathogen-encoded effectors target the Met1-linked ubiquitin machinery to subvert host-defence responses.
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Met1-Diubiquitin,Catalog Number: U2101,Lyophilized,Purity≥95%
Met1-Diubiquitin chains are manufactured using recombinant methods.
Met1-linked ubiquitin chains are key regulators of inflammation and immunity to pathogens. Met1-linked ubiquitin chains are assembled by LUBAC and are disassembled by the deubiquitinases OTULIN and CYLD. Met1-linked ubiquitin chains function as kinase scaffolds to control signalling outcomes by pattern recognition receptors and cytokine receptors. Intracellular bacteria are decorated with Met1-linked ubiquitin chains for activation of xenophagy. Pathogen-encoded effectors target the Met1-linked ubiquitin machinery to subvert host-defence responses.