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K63-Diubiquitin,Catalog Number: U2801,Lyophilized,Purity95% This K63 linked di-ubiquitin was obtained by chemical synthesis. K63-linked polyubiquitin chains exert nonproteolytic functions in vivo, such as protein trafficking, kinase/phosphatase activation, and DNA damage control, all of which might be important in regulation of cancer survival and development. The array of cellular processes initiated and regulated by ubiquitin has been partially explained by the structural

K27-Diubiquitin Catalog Number U2401 Lyophilized Purity95% This K27 linked di-ubiquitin was obtained by chemical synthesis. K27-linkage poly-ubiquitination plays important roles in DNA damage repair and autoimmunity. Recently reports have emerged that place K27 chains mainly in the intracellular innate immune response pathway, where they regulate several essential infection sensors, such as STING, cGAS, MAVS, and MDA5, or effectors such as NEMO and Beclin.

Types of histone modification Chromatin architecture, nucleosomal positioning, and ultimately access to DNA for gene transcription, is largely controlled by histone proteins. Each nucleosome is made of two identical subunits, each of which contains four histones: H2A, H2B, H3, and H4. Meanwhile, the H1 protein acts as the linker histone to stabilize internucleosomal DNA and does not form part of the nucleosome itself. Histone proteins undergo post-translational modification