k48 linked ubiquitin proteins online manufacturer Manufacturer

K48-Diubiquitin,Catalog Number: U2701,Lyophilized,Purity95% This K48 linked di-ubiquitin was obtained by chemical synthesis. Proteins polyubiquinated at specific lysine residues display a tendency to be targeted for different processes. The attachment of K48-linked polyubiquitin chains to proteins is a universal signal for degradation by the proteasome.

K63-Diubiquitin,Catalog Number: U2801,Lyophilized,Purity95% This K63 linked di-ubiquitin was obtained by chemical synthesis. K63-linked polyubiquitin chains exert nonproteolytic functions in vivo, such as protein trafficking, kinase/phosphatase activation, and DNA damage control, all of which might be important in regulation of cancer survival and development. The array of cellular processes initiated and regulated by ubiquitin has been partially explained by the structural

Ubiquitin (Ub) is ubiquitous. This small, 76-residue protein is used to mark cellular proteins for degradation by the ubiquitin proteasome system (UPS). Two key enzyme families, Ub ligases and deubiquitylation enzymes (DUBs), are responsible for putting on and taking off these Ub units and controlling the overall protein population of the cell. As you might imagine, this dynamic process is important, and dysregulation can lead to an array of bad things. Thus, understanding