k29 ubiquitin probes online manufacturer Manufacturer

K29-Diubiquitin,Catalog Number: U2501,Lyophilized,Purity95% This K29 linked di-ubiquitin was obtained by chemical synthesis. K29 linked polyubiquitination has been shown to be an inhibitor of Wnt signaling, which plays an important role in embryogenesis, and its deregulation has been shown to play a role in tumorigenesis.

K63-Diubiquitin,Catalog Number: U2801,Lyophilized,Purity95% This K63 linked di-ubiquitin was obtained by chemical synthesis. K63-linked polyubiquitin chains exert nonproteolytic functions in vivo, such as protein trafficking, kinase/phosphatase activation, and DNA damage control, all of which might be important in regulation of cancer survival and development. The array of cellular processes initiated and regulated by ubiquitin has been partially explained by the structural

Ubiquitin (Ub) is ubiquitous. This small, 76-residue protein is used to mark cellular proteins for degradation by the ubiquitin proteasome system (UPS). Two key enzyme families, Ub ligases and deubiquitylation enzymes (DUBs), are responsible for putting on and taking off these Ub units and controlling the overall protein population of the cell. As you might imagine, this dynamic process is important, and dysregulation can lead to an array of bad things. Thus, understanding