synthesized histones proteins online manufacturer Manufacturer

H3-K27me1 Catalog Number H3107 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, monomethylation at K27. H3K27me1 is linked to promotion of transcription and is seen to accumulate in transcribed genes. Histone-histone interactions play a role in this process. Regulation occurs via Setd2-dependent H3K36me3 deposition. H3K27me1 shows an inverse distribution to H3K27me3 that defines the

H3-T118ph Catalog Number H3302 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, acetylation at K122. H3K122ac can be sufficient to stimulate transcription and that mutation of H3K122 impairs transcriptional activation. H3K122ac defines genome-wide genetic elements and chromatin features associated with active transcription. H3K122ac is catalyzed by the coactivators p300/CBP and can be

H4-K16ac Catalog Number H4203 Lyophilized Store At -20C Or -80C Chemically synthesized histone H4 protein, corresponding to residues within 1-102 of human histone H4, acetylation at K16. H4K16ac is an epigenetic modification to the DNA packaging protein Histone H4. It is a mark that indicates the acetylation at the 16th lysine residue of the histone H4 protein. H4K16ac is unusual in that it has both transcriptional activation AND repression activities. The loss of H4K20me3

H4-K8ac Catalog Number H4201 Lyophilized Store At -20C Or -80C Chemically synthesized histone H4 protein, corresponding to residues within 1-102 of human histone H4, acetylation at K8. H4K8ac, representing an epigenetic modification to the DNA packaging protein histone H4, is a mark indicating the acetylation at the 8th lysine residue of the histone H4 protein. It has been implicated in the prevalence of malaria.

H4-K12ac Catalog Number H4202 Lyophilized Store At -20C Or -80C Chemically synthesized histone H4 protein, corresponding to residues within 1-102 of human histone H4, acetylation at K12. H4K12ac is an epigenetic modification to the DNA packaging protein histone H4. It is a mark that indicates the acetylation at the 12th lysine residue of the histone H4 protein. H4K12ac is involved in learning and memory. It is possible that restoring this modification could reduce age

H3K27me2 Catalog Number H3108 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, dimethylationat K27. H3K27me2 is broadly distributed within the core histone H3 and is believed to play a protective role by inhibiting non-cell-type specific enhancers. Ultimately, this leads to the inactivation of transcription. In mouse embryonic stem cells, H3K27me2 is the dominant modification form,

H3-K36me3 Catalog Number H3113 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, Asymmetric dimethylation at R42. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H3R42me2a is a histone modification with positive transcriptional effects. Nucleosomes containing H3R42me2a can stimulate

H3-K56ac Catalog Number H3201 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, acetylation at K56. H3K56ac is a covalent modification known as a mark of newly replicated chromatin as well as replication-independent histone replacement. H3K56ac is important for chromatin remodeling and serves as a marker of new nucleosomes during DNA replication but its role in the cell cycle is debated.

H4-K5ac Catalog Number H4205 Lyophilized Store At -20C Or -80C Chemically synthesized histone H4 protein, corresponding to residues within 1-102 of human histone H4, acetylation at K5. H4K5 is acetylated by TIP60 and CBP/p300 proteins. CAP/p300 open transcriptional start site chromatin by acetylating histones. H4K5ac has also been implicated in epigenetic bookmarking which allows gene expression patterns to be faithfully passed to daughter cells through mitosis. Important

H3K4me3 Catalog Number H3103 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, trimethylation at K4. H3K4me3 is commonly associated with the activation of transcription of nearby genes. H3K4 trimethylation regulates gene expression through chromatin remodeling by the NURF complex. This makes the DNA in the chromatin more accessible for transcription factors, allowing the genes to be