human histone ubiquitylation online manufacturer Manufacturer

Ub-Rho110,Catalog Number: UU1030,Lyophilized,Purity95% Ubiquitin-Rho110 is prepared by the C-terminal derivatization of ubiquitin with rhodamine 110. Compared with Ub-AMC, Ub-Rho110 has excitation and emission wavelengths ranging from 490 to 550 nm, it can effectively reduce the false positive results caused by autofluorescence of compounds.

Types of histone modification Chromatin architecture, nucleosomal positioning, and ultimately access to DNA for gene transcription, is largely controlled by histone proteins. Each nucleosome is made of two identical subunits, each of which contains four histones: H2A, H2B, H3, and H4. Meanwhile, the H1 protein acts as the linker histone to stabilize internucleosomal DNA and does not form part of the nucleosome itself. Histone proteins undergo post-translational modification

H2B-K34Ub Catalog Number H2401 Store at -20C or -80C Chemically synthesized histone H2B protein corresponding to residues within 1-125 of human histone H2B with K34 monoubiquitination. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H2B-K34ub modification is sufficient to promote selective eviction of only one H2A/H2B dimer independently of histone-binding agents. H2B K34

H2A-K15Ub Catalog Number H1402 Store at -20C or -80C Chemically synthesized histone H2A protein (1-129,human) with mono-ubiquitination at K15. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. RNF168-mediated ubiquitination of histone H2A Lys13,15 (H2AK13,15ub) at DNA double-strand breaks (DSBs) is crucial for preventing aberrant DNA repair and maintaining genome stability.