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H4-K20me2 Catalog Number H4101 Lyophilized Store At -20C Or -80C Chemically synthesized histone H4 protein, corresponding to residues within 1-102 of human histone H4, dimethylation at K20. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H4K20me2 is the most common methylation state on histone H4 and was one of the earliest modified histone residues to be identified back

H3K9me3 Catalog Number H3106 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, trimethylation at K9. H3K9me3 is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the tri-methylation at the 9th lysine residue of the histone H3 protein and is often associated with heterochromatin. Nomenclature Abbr. Meaning H3 H3 family of histones K standard

H3-K36me2 Catalog Number H3111 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, dimethylation at K36. H3K36me2 is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the di-methylation at the 36th lysine residue of the histone H3 protein. NSD1-mediated H3K36me2 is required for the recruitment of DNMT3A and maintenance of DNA methylation at

H3-K79me2 Catalog Number H3114 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, Asymmetric dimethylation at R42. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H3R42me2a is a histone modification with positive transcriptional effects. Nucleosomes containing H3R42me2a can stimulate

H4-K20ac Catalog Number H4204 Lyophilized Store At -20C Or -80C Chemically synthesized histone H4 protein, corresponding to residues within 1-102 of human histone H4, acetylation at K20. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H4K20ac is associated with gene repression in human cells. Unlike H3K9me3, a constitutive heterochromatin mark, H4K20ac was less associated

Types of histone modification Chromatin architecture, nucleosomal positioning, and ultimately access to DNA for gene transcription, is largely controlled by histone proteins. Each nucleosome is made of two identical subunits, each of which contains four histones: H2A, H2B, H3, and H4. Meanwhile, the H1 protein acts as the linker histone to stabilize internucleosomal DNA and does not form part of the nucleosome itself. Histone proteins undergo post-translational modification

H2B-K120Ub Catalog Number H2402 Store at -20C or -80C Chemically synthesized histone H2B protein corresponding to residues within 1-125 of human histone H2B with K120 monoubiquitination. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H2B-K120ub is a prominent histone posttranslational modification (PTM) associated with the actively transcribed genome. H2B-K120ub act as a

H2A-K15Ub Catalog Number H1402 Store at -20C or -80C Chemically synthesized histone H2A protein (1-129,human) with mono-ubiquitination at K15. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. RNF168-mediated ubiquitination of histone H2A Lys13,15 (H2AK13,15ub) at DNA double-strand breaks (DSBs) is crucial for preventing aberrant DNA repair and maintaining genome stability.

H2B-S14ph Catalog Number H2301 Store at -20C or -80C Chemically synthesized histone H2B protein corresponding to residues within 1-125 of human histone H2B with phosphorylation S14 modification. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. Phosphorylation of histone H2B at serine 14 (H2B-S14Ph) is associated with DNA damage and induces apoptotic chromatin condensation.

H2B-K34Ub Catalog Number H2401 Store at -20C or -80C Chemically synthesized histone H2B protein corresponding to residues within 1-125 of human histone H2B with K34 monoubiquitination. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H2B-K34ub modification is sufficient to promote selective eviction of only one H2A/H2B dimer independently of histone-binding agents. H2B K34