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H3-K36me3 Catalog Number H3112 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, trimethylation at K36. H3K36me3 can bind chromodomain proteins such as MSL3 hMRG15 and scEaf3. It can bind PWWP proteins such as BRPF1 DNMT3A, HDGF2 and Tudor domains such as PHF19 and PHF1. H3K36me3 is required for homologous recombinational repair of DNA damage such as double-strand breaks. The trimethylati

H3-K79me2 Catalog Number H3114 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, Asymmetric dimethylation at R42. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H3R42me2a is a histone modification with positive transcriptional effects. Nucleosomes containing H3R42me2a can stimulate

K6-Diubiquitin,Catalog Number: U2201,Lyophilized,Purity95% This K6 linked di-ubiquitin was obtained by chemical synthesis. K6 linked ubiquitin linkages are found at increased levels in response to UV radiation, indirectly associated with DNA repair, and have been identified on mitochondrial outer membrane (MOM) proteins. Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australia,Asia,Middle East,Africa

Types of histone modification Chromatin architecture, nucleosomal positioning, and ultimately access to DNA for gene transcription, is largely controlled by histone proteins. Each nucleosome is made of two identical subunits, each of which contains four histones: H2A, H2B, H3, and H4. Meanwhile, the H1 protein acts as the linker histone to stabilize internucleosomal DNA and does not form part of the nucleosome itself. Histone proteins undergo post-translational modification

Histone H2A Catalog Number H1300 Store at -20C or -80C Histone H2A is one of the four core histone proteins involved in the structure of chromatin in eukaryotic cells. H2A is important for packaging DNA into chromatin and has been found to regulate gene expression. This product is expressed in E.coli and composed of 129 amino acids. Structure H2A consists of a main globular domain, an N-terminal tail and a C-terminal tail. Both tails are the location of post-translational

H2B Catalog Number H2300 Store at -20C or -80C This product is an expressed human H2B protein composed of 125 amino acids. Histone H2B is one of the 4 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and long N-terminal and C-terminal tails, H2B is involved with the structure of the nucleosomes and helps organize eukaryotic DNA. It plays an important role in the biology of the nucleus where it is involved in

H2A-K15Ub Catalog Number H1402 Store at -20C or -80C Chemically synthesized histone H2A protein (1-129,human) with mono-ubiquitination at K15. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. RNF168-mediated ubiquitination of histone H2A Lys13,15 (H2AK13,15ub) at DNA double-strand breaks (DSBs) is crucial for preventing aberrant DNA repair and maintaining genome stability.

H2A-K13Ub Catalog Number H1401 Store at -20C or -80C This product is chemically synthesized histone H2A protein (1-129, human) with mono-ubiquitination at K13. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. RNF168-mediated ubiquitination of histone H2A Lys13,15 (H2AK13,15ub) at DNA double-strand breaks (DSBs) is crucial for preventing aberrant DNA repair and maintaining

H2A.ZK121Ub Catalog Number H1404 Store at -20C or -80C Chemically synthesized histone H2A.Z protein corresponding to residues with monoubiquitination K121 modification. The histone variant H2A.Z has been implicated in nucleosome exchange, transcriptional activation and Polycomb repression. H2A.Z has been shown to be subject to C-terminal ubiquitination by the PRC1 component Ring1B. Histone H2AZ is a variant of histone H2A, and is used to mediate the thermosensory response,

H2B-S14ph Catalog Number H2301 Store at -20C or -80C Chemically synthesized histone H2B protein corresponding to residues within 1-125 of human histone H2B with phosphorylation S14 modification. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. Phosphorylation of histone H2B at serine 14 (H2B-S14Ph) is associated with DNA damage and induces apoptotic chromatin condensation.