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GsMTx-4,Catalog Number: O1080-V,CAS#:1209500-46-8,Lyophilized,Purity≥95%
Mechanosensitive and stretch-activated ion channel inhibitor.
Grammostola mechanotoxin #4 (GsMTx-4, GsMTx4, GsMTx-IV), also known as M-theraphotoxin-Gr1a (M-TRTX-Gr1a), is a neurotoxin isolated from the venom of the spider Chilean rose tarantula Grammostola spatulate (or Grammostola rosea).This amphiphilic peptide, which consists of 35 amino acids, belongs to the inhibitory cysteine knot (ICK) peptide family. It reduces mechanical sensation by inhibiting mechanosensitive channels (MSCs).
GsMTx-4 also serves as a cationic antimicrobial peptide against Gram-positive bacteria.
Source.
GsMTx-4 was isolated from the venom of Grammostola spatulata. After a blocking effect on mechanosensitive channels of the spider venom was detected in 1996, GsMTx-4 was isolated and identified from the venom later in 2000. Its concentration in the venom is ∼2 mM.
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GsMTx-4,Catalog Number: O1080-V,CAS#:1209500-46-8,Lyophilized,Purity≥95%
Mechanosensitive and stretch-activated ion channel inhibitor.
Grammostola mechanotoxin #4 (GsMTx-4, GsMTx4, GsMTx-IV), also known as M-theraphotoxin-Gr1a (M-TRTX-Gr1a), is a neurotoxin isolated from the venom of the spider Chilean rose tarantula Grammostola spatulate (or Grammostola rosea).This amphiphilic peptide, which consists of 35 amino acids, belongs to the inhibitory cysteine knot (ICK) peptide family. It reduces mechanical sensation by inhibiting mechanosensitive channels (MSCs).
GsMTx-4 also serves as a cationic antimicrobial peptide against Gram-positive bacteria.
Source.
GsMTx-4 was isolated from the venom of Grammostola spatulata. After a blocking effect on mechanosensitive channels of the spider venom was detected in 1996, GsMTx-4 was isolated and identified from the venom later in 2000. Its concentration in the venom is ∼2 mM.