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MALDI-TOF MS Technology Can Help Customers in The Following Aspects:
There are differences in the sequence and size of ribosomal proteins and some housekeeping proteins (usually 2-20kDa) between different bacterial species. These ribosomal proteins account for about 60-70% of the dry weight of microbial cells. MALDI-TOF MS can obtain the peptide mass fingerprint through the detection of microbial samples, and compare it with peptide fingerprint libraries to achieve species level identification of microorganisms. MALDI-TOF MS is a simple and convenient microbial identification technology, which greatly shortens the time required for microbial identification.
As a proteomics technology, MALDI-TOF MS can not only be used as a tool for microbial identification, but also as an efficient and sensitive tool for strain typing. For example, MALDI-TOF MS can be used for typing and characterization of beta hemolytic streptococci, streptococci group A, Vibrio spp., Y. enterocolitica, etc.
MALDI-TOF MS is also often used for antimicrobial susceptibility testing (AST). The resistance of microorganisms to β-lactam antibiotics depends on the expression of β-lactamase, which can hydrolyze the β-lactam ring and thereby inactivate this antibiotic. This hydrolysis process caused an 18 Da mass change, and this mass change caused by the degradation of antibiotics can be detected by MALDI-TOF MS technology. In addition, MALDI-TOF MS can be used to find specific biomarkers of antibiotic resistant strains, as well as phenotypic antibiotic resistance analysis of bacterial strains, so as to obtain AST results in a shorter time.
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MALDI-TOF MS Technology Can Help Customers in The Following Aspects:
There are differences in the sequence and size of ribosomal proteins and some housekeeping proteins (usually 2-20kDa) between different bacterial species. These ribosomal proteins account for about 60-70% of the dry weight of microbial cells. MALDI-TOF MS can obtain the peptide mass fingerprint through the detection of microbial samples, and compare it with peptide fingerprint libraries to achieve species level identification of microorganisms. MALDI-TOF MS is a simple and convenient microbial identification technology, which greatly shortens the time required for microbial identification.
As a proteomics technology, MALDI-TOF MS can not only be used as a tool for microbial identification, but also as an efficient and sensitive tool for strain typing. For example, MALDI-TOF MS can be used for typing and characterization of beta hemolytic streptococci, streptococci group A, Vibrio spp., Y. enterocolitica, etc.
MALDI-TOF MS is also often used for antimicrobial susceptibility testing (AST). The resistance of microorganisms to β-lactam antibiotics depends on the expression of β-lactamase, which can hydrolyze the β-lactam ring and thereby inactivate this antibiotic. This hydrolysis process caused an 18 Da mass change, and this mass change caused by the degradation of antibiotics can be detected by MALDI-TOF MS technology. In addition, MALDI-TOF MS can be used to find specific biomarkers of antibiotic resistant strains, as well as phenotypic antibiotic resistance analysis of bacterial strains, so as to obtain AST results in a shorter time.