Peptide live Show No. 10 || Developing new condensation reagents and exploring green synthesis of polypeptides

Broadcast time and theme

Time: 19:00, Friday, February 10, 2023

Topic: Developing new condensation reagents and exploring green synthesis of polypeptides

Live Guest profile

Dr. Zhao Junfeng, Professor and doctoral supervisor of Guangzhou Medical University. Fellow of the Royal Society of Chemistry, Humboldt Scholar in Germany. Ph.D., Nanyang Technological University, Singapore (2010), postdoctoral research at Nanyang Technological University, Singapore, University of Bonn, Germany, and University of Munster. He was a research assistant professor at the University of Hong Kong, a professor and doctoral supervisor at Jiangxi Normal University and Northwestern Polytechnical University. At J. Am. Chem.Soc., Angew. Chem.Int.Ed. More than 50 papers have been published in internationally renowned magazines. He has presided over more than 10 national, provincial and ministerial projects, including major research programs and surface projects of the National Natural Science Foundation. He won The National Scholarship for Outstanding Self-Funded Foreign Students, Reaxys PhD Prize Finalist, Thieme Chemistry Journals Award, and The Distinguished Lectureship of the Chemical Society of Japan Award ", Raffles Green Pharmaceutical Innovation Award, China Peptide Industry Alliance Innovation Award, Young Peptide Scientist Award, Chinese Overseas Chinese Community Contribution Award, and selected for the Ministry of Human Resources and Social Security high-level talents returned to China funding program.

Summary of report

Professor Zhao Junfeng focuses on the research in the frontier areas of chemistry and life science, and solves key scientific problems in the field of chemical biology by developing new reactions and new reagents in organic chemistry. After eight years of hard work, Professor Zhao Junfeng has achieved original and systematic research results in the field of chemical synthesis and precise modification of peptides and proteins. Professor Zhao Junfeng proposed the concept of condensation reagent design with alkenyl activated ester as the stable intermediate, and discovered two original polypeptide condensation reagents of acetylenamide and dienone, which provided a powerful tool for solving the racemization problem of the chiral center of α-amino acids in the synthesis of polypeptides. These two compounds can greatly reduce the production cost of peptide drugs, not only have important academic value, but also have broad application prospects in large-scale synthesis of peptide drugs, and are expected to provide transformative solutions for large-scale green production of peptide drugs. In this report, Professor Zhao Junfeng will detail the research progress of these two condensation reagents and explore the challenges and opportunities for green synthesis of polypeptides.