lyophilized histones online manufacturer Manufacturer

H3-K36me3 Catalog Number H3112 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, trimethylation at K36. H3K36me3 can bind chromodomain proteins such as MSL3 hMRG15 and scEaf3. It can bind PWWP proteins such as BRPF1 DNMT3A, HDGF2 and Tudor domains such as PHF19 and PHF1. H3K36me3 is required for homologous recombinational repair of DNA damage such as double-strand breaks. The trimethylati

H3-K18ac Catalog Number H3202 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, acetylation at K18. Acetylation and deacetylation are posttranslational modifications (PTMs) which affect the regulation of chromatin structure and its remodeling. Acetylation of histone 3 at lysine placed on position 18 (H3K18Ac) plays an important role in driving progression of many types of cancer,

H3-T118ph Catalog Number H3302 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, acetylation at K122. H3K122ac can be sufficient to stimulate transcription and that mutation of H3K122 impairs transcriptional activation. H3K122ac defines genome-wide genetic elements and chromatin features associated with active transcription. H3K122ac is catalyzed by the coactivators p300/CBP and can be

H4-K20ac Catalog Number H4204 Lyophilized Store At -20C Or -80C Chemically synthesized histone H4 protein, corresponding to residues within 1-102 of human histone H4, acetylation at K20. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H4K20ac is associated with gene repression in human cells. Unlike H3K9me3, a constitutive heterochromatin mark, H4K20ac was less associated

H3K27me3 Catalog Number H3109 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, trimethylation at K27. H3K27me3 is often seen to interact with H3K4me3 in bivalent domains . These domains are usually found in embryonic stem cells and are pivotal for proper cell differentiation. H3K27me3 and H3K4me3 determine whether a cell will remain unspecified or will eventually differentiate. The Grb10

H3K36me1 Catalog Number H3110 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, monomethylation at K36. The methylation of H3K36 has particularly had effects in transcriptional repression, alternative splicing, dosage compensation, DNA replication and repair, DNA methylation, and the transmission of the memory of gene expression from parents to offspring during development. set2 mutants

H3-K122ac Catalog Number H3204 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, acetylation at K122. H3K122ac can be sufficient to stimulate transcription and that mutation of H3K122 impairs transcriptional activation. H3K122ac defines genome-wide genetic elements and chromatin features associated with active transcription. H3K122ac is catalyzed by the coactivators p300/CBP and can be

H3-S10ph Catalog Number H3301 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, acetylation at K122. H3K122ac can be sufficient to stimulate transcription and that mutation of H3K122 impairs transcriptional activation. H3K122ac defines genome-wide genetic elements and chromatin features associated with active transcription. H3K122ac is catalyzed by the coactivators p300/CBP and can be

CENPA-S68ph Catalog Number C16368 Lyophilized Store At -20C Or -80C Synthesized peptide corresponding to residues within 1-140 of CENP A with phosphorylation S68 modification. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. Phosphorylation of Ser68 eliminates the binding of CENP-A to the assembly factor HJURP, thus preventing the premature loading of CENP-A to the

Ub-Rho110,Catalog Number: UU1030,Lyophilized,Purity95% Ubiquitin-Rho110 is prepared by the C-terminal derivatization of ubiquitin with rhodamine 110. Compared with Ub-AMC, Ub-Rho110 has excitation and emission wavelengths ranging from 490 to 550 nm, it can effectively reduce the false positive results caused by autofluorescence of compounds.