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Ub-Prg,Catalog Number: U1040,Lyophilized,Purity95%,Molecular Weight:8588.79 Ubiquitin-Prg is C-terminally propargylated Ub. Ub-Prg (also called Ub-PA) can react with the active Cys of DUBs through 1,2-addition to produce a stable vinyl thioether product. To explain regulatory mechanisms, Ub-Prg was used to capture the catalytic conformation by which RPN13DEUBAD activates UCH-L5; and the catalytic conformation that truncated INO80DEUBAD lacks to inhibit UCH-L5.
