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H3-K122ac Catalog Number H3204 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, acetylation at K122. H3K122ac can be sufficient to stimulate transcription and that mutation of H3K122 impairs transcriptional activation. H3K122ac defines genome-wide genetic elements and chromatin features associated with active transcription. H3K122ac is catalyzed by the coactivators p300/CBP and can be

H3-K64ac Catalog Number H3203 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, acetylation at K64. Histone H3 is reported to be acetylated at Lys64 (H3K64ac) by p300 co-activator. In addition, H3K64ac is found enriched at the transcriptional start sites of active genes, consistent with a transcriptional activation modification opposite of its repressive counterpart H3K64me3.

H3-T118ph Catalog Number H3302 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, acetylation at K122. H3K122ac can be sufficient to stimulate transcription and that mutation of H3K122 impairs transcriptional activation. H3K122ac defines genome-wide genetic elements and chromatin features associated with active transcription. H3K122ac is catalyzed by the coactivators p300/CBP and can be

H3-K79me2 Catalog Number H3114 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, Asymmetric dimethylation at R42. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H3R42me2a is a histone modification with positive transcriptional effects. Nucleosomes containing H3R42me2a can stimulate

H3-K36me3 Catalog Number H3112 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, trimethylation at K36. H3K36me3 can bind chromodomain proteins such as MSL3 hMRG15 and scEaf3. It can bind PWWP proteins such as BRPF1 DNMT3A, HDGF2 and Tudor domains such as PHF19 and PHF1. H3K36me3 is required for homologous recombinational repair of DNA damage such as double-strand breaks. The trimethylati

H3-K18ac Catalog Number H3202 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, acetylation at K18. Acetylation and deacetylation are posttranslational modifications (PTMs) which affect the regulation of chromatin structure and its remodeling. Acetylation of histone 3 at lysine placed on position 18 (H3K18Ac) plays an important role in driving progression of many types of cancer,

H3-K56ac Catalog Number H3201 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, acetylation at K56. H3K56ac is a covalent modification known as a mark of newly replicated chromatin as well as replication-independent histone replacement. H3K56ac is important for chromatin remodeling and serves as a marker of new nucleosomes during DNA replication but its role in the cell cycle is debated.

H3-S10ph Catalog Number H3301 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, acetylation at K122. H3K122ac can be sufficient to stimulate transcription and that mutation of H3K122 impairs transcriptional activation. H3K122ac defines genome-wide genetic elements and chromatin features associated with active transcription. H3K122ac is catalyzed by the coactivators p300/CBP and can be

H4-K20ac Catalog Number H4204 Lyophilized Store At -20C Or -80C Chemically synthesized histone H4 protein, corresponding to residues within 1-102 of human histone H4, acetylation at K20. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H4K20ac is associated with gene repression in human cells. Unlike H3K9me3, a constitutive heterochromatin mark, H4K20ac was less associated

H3K36me1 Catalog Number H3110 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, monomethylation at K36. The methylation of H3K36 has particularly had effects in transcriptional repression, alternative splicing, dosage compensation, DNA replication and repair, DNA methylation, and the transmission of the memory of gene expression from parents to offspring during development. set2 mutants