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H3K4me3 Catalog Number H3103 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, trimethylation at K4. H3K4me3 is commonly associated with the activation of transcription of nearby genes. H3K4 trimethylation regulates gene expression through chromatin remodeling by the NURF complex. This makes the DNA in the chromatin more accessible for transcription factors, allowing the genes to be

H4-K20ac Catalog Number H4204 Lyophilized Store At -20C Or -80C Chemically synthesized histone H4 protein, corresponding to residues within 1-102 of human histone H4, acetylation at K20. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H4K20ac is associated with gene repression in human cells. Unlike H3K9me3, a constitutive heterochromatin mark, H4K20ac was less associated

H3K27me2 Catalog Number H3108 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, dimethylationat K27. H3K27me2 is broadly distributed within the core histone H3 and is believed to play a protective role by inhibiting non-cell-type specific enhancers. Ultimately, this leads to the inactivation of transcription. In mouse embryonic stem cells, H3K27me2 is the dominant modification form,

H3-K36me2 Catalog Number H3111 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, dimethylation at K36. H3K36me2 is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the di-methylation at the 36th lysine residue of the histone H3 protein. NSD1-mediated H3K36me2 is required for the recruitment of DNMT3A and maintenance of DNA methylation at

H3-K56ac Catalog Number H3201 Lyophilized Store At -20C Or -80C Chemically synthesized histone H3 protein, corresponding to residues within 1-135 of human histone H3, acetylation at K56. H3K56ac is a covalent modification known as a mark of newly replicated chromatin as well as replication-independent histone replacement. H3K56ac is important for chromatin remodeling and serves as a marker of new nucleosomes during DNA replication but its role in the cell cycle is debated.

H2B-K120Ub Catalog Number H2402 Store at -20C or -80C Chemically synthesized histone H2B protein corresponding to residues within 1-125 of human histone H2B with K120 monoubiquitination. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H2B-K120ub is a prominent histone posttranslational modification (PTM) associated with the actively transcribed genome. H2B-K120ub act as a

H2A-Y57ph Catalog Number H1301 Store at -20C or -80C This product is chemically synthesized histone H2A protein(1-129,human) with phosphorylation at Y57. Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H2A-Y57ph inhibits deubiquitination of H2B by the SAGA complex as well as restricting demethylation of H3 and increasing its acetylation. Based on CK2 dependent tyrosine57

H2A.ZK121Ub Catalog Number H1404 Store at -20C or -80C Chemically synthesized histone H2A.Z protein corresponding to residues with monoubiquitination K121 modification. The histone variant H2A.Z has been implicated in nucleosome exchange, transcriptional activation and Polycomb repression. H2A.Z has been shown to be subject to C-terminal ubiquitination by the PRC1 component Ring1B. Histone H2AZ is a variant of histone H2A, and is used to mediate the thermosensory response,