u1020 ubiquitin probes online manufacturer Manufacturer

Ub-ACC,Catalog Number: U1020,Lyophilized,Purity95%,Molecular Weight:8765.4 Ubiquitin-ACC is prepared by the C-terminal derivatization of ubiquitin with 7-amino-4-carbamoylmethylcoumarin. Ubiquitin-ACC is a fluorogenic substrate for a wide range of deubiquitinating enzymes (DUBs), including ubiquitin C-terminal hydrolases (UCHs) and ubiquitin specific proteases (USPs). It is a particularly useful reagent for the study of deubiquitinating activity where detection sensitivity

Ubiquitin (Ub) is ubiquitous. This small, 76-residue protein is used to mark cellular proteins for degradation by the ubiquitin proteasome system (UPS). Two key enzyme families, Ub ligases and deubiquitylation enzymes (DUBs), are responsible for putting on and taking off these Ub units and controlling the overall protein population of the cell. As you might imagine, this dynamic process is important, and dysregulation can lead to an array of bad things. Thus, understanding