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biotin labeled Steroid Receptor Coactivator-1 (SRC-1),Catalog Number: KS141002
The present peptide represents amino acids 676 to 700 of the steroid receptor co-activator 1 (SRC1) sequence and has been biotinylated at the N-terminus. This segment corresponds to the second LXXLL motif of SRC1, located within a short amphipathic beta-helical domain that acts as the interface for interaction between co-activator proteins and nuclear receptors. Co-activator proteins modulate transcription by binding nuclear receptors in a ligand-dependent manner. The ligand-dependent activation function 2 (AF-2) domain, situated at the COOH-terminus of the nuclear receptor ligand-binding domain (LBD), engages with the SRC1 LXXLL motif. Notably, the receptor binding domain of SRC1 shows specific recruitment to the farnesoid X receptor (FXR) ligand-binding domain.
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biotin labeled Steroid Receptor Coactivator-1 (SRC-1),Catalog Number: KS141002
The present peptide represents amino acids 676 to 700 of the steroid receptor co-activator 1 (SRC1) sequence and has been biotinylated at the N-terminus. This segment corresponds to the second LXXLL motif of SRC1, located within a short amphipathic beta-helical domain that acts as the interface for interaction between co-activator proteins and nuclear receptors. Co-activator proteins modulate transcription by binding nuclear receptors in a ligand-dependent manner. The ligand-dependent activation function 2 (AF-2) domain, situated at the COOH-terminus of the nuclear receptor ligand-binding domain (LBD), engages with the SRC1 LXXLL motif. Notably, the receptor binding domain of SRC1 shows specific recruitment to the farnesoid X receptor (FXR) ligand-binding domain.