The in vivo behavior and biological activity of peptides is intimately related to their chemical structure. Following the confirmation of lead peptide(s), they need to be modified using medicinal chemistry techniques to improve their biological activity and achieve selectivity, stability, and solubility of the peptide drugs.

The peptide modification services at KS-V Peptide offer a wide range of modifications to meet your research needs. These modifications can improve overall peptide stability, alter structure to better understand biological function, or enhance immunogenicity for antibody development and production. Our peptide modification services include, but is not limited to post-translational modifications, e.g., phosphorylation, acylation, methylation, etc.; protein modifications, e.g., Ubiquitination; as well as other chemical modifications, e.g., fluorescence labeling, bioorthogonal handles, PEGylation, DOTA labeling, palmitoylation, and other lipid modifications for peptide preparation.

In addition to various sidechain modifications, KS-V Peptide services also include peptide backbone modifications, including D-amino acid substitutions, insertion of methyl-amino acids, incorporation of β-amino acids and peptoids, α-helices mimics and different peptide cyclization strategies.